KPV: The Gut Peptide That Targets Inflammation at the Source
KPV — the tripeptide derived from alpha-MSH studied for gut inflammation, intestinal permeability, and immune modulation. What the research shows. USA manufactured, >99% purity. For Research Use Only.
Jul 3, 2026 | 13 min Read
What Is KPV?
KPV stands for Lysine-Proline-Valine – a naturally occurring tripeptide and the C-terminal fragment of alpha-Melanocyte Stimulating Hormone (alpha-MSH).
Alpha-MSH is a peptide hormone produced in the pituitary gland with well-documented anti-inflammatory and immunomodulatory properties. KPV retains the anti-inflammatory activity of its parent hormone without the melanotropic (skin-darkening) side effects – making it a more targeted research tool for studying inflammation and gut biology.
KPV has attracted significant research interest for its effects on intestinal inflammation, gut barrier integrity, and NF-kB signaling – the master transcription factor controlling the inflammatory response. It is one of the few research compounds studied specifically for its relevance to inflammatory bowel conditions, making it of particular interest to the Celiac, Crohn’s, and ulcerative colitis research communities.
BetterBio Synthesis carries KPV for research use – US manufactured, third-party tested, COA verified.
CAS Number: 66003-30-3
Molecular Formula: C16H30N4O5
Molecular Weight: 358.4 g/mol
⚠️ KPV is not FDA approved for human therapeutic use. All research discussed is preclinical or early-stage. For Research Use Only.
How Does KPV Work? (Mechanism of Action)
KPV operates through several well-characterized mechanisms that are particularly relevant to gut health and inflammation research.
